Computer-based instructional applications are considered an effective alternative to traditional teaching methods and today in numerous educational and training settings, interactive computer programs are used to teach young students and adults computer literacy skills. The purpose of this study is to compare the attitudes and motivations of students who attended a computer-based in-class computer literacy course with the attitudes and motivations of those who participated in a classical lecture-based computer literacy course. The results show that there is no significant difference between computer-based instruction group students’ and lecture-based instruction group students’ total attitudes scores. However, a significant instructional mode effect on students’ motivation was detected.