Science, technology, engineering, and mathematics (STEM) education has recently emerged as a mainstream way for the global education community to address global crisis issues. This systematic review provides an in-depth overview of international STEM researcher collaborations and trends in STEM education’s most recent research topics. We examined 49 peer-reviewed articles selected from 244 articles published in three reputable international journals from January 2014 to December 2018. We used inclusion criteria, percent agreement, and Cohen’s kappa coefficient to reduce research bias. There is an urgent desire to understand why STEM education research trends increase significantly each year. Goals, policies, curriculum, and assessment continue to dominate research topics. Our findings highlight the essential points in implementing STEM education that can be used as a base for future planning. Researchers and stakeholders can use several aspects of the findings to understand how effective carefully preparing school interventions can be. However, it appears that international collaboration among STEM researchers is still minimal. Cross-country and cross-cultural research collaboration should be promoted to play an essential role in maximizing STEM research and dissemination.